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. 2014 Jun;50(6):1129–1135. doi: 10.1165/rcmb.2013-0434OC

Figure 3.

Figure 3.

Effect of nmMLCK silencing on asthmatic inflammation in mice. WT mice received nmMLCK small interfering RNA (siRNA) to reduce nmMLCK expression in the lungs, and were challenged by OVA to activate asthmatic inflammation. (A) Effects of nmMLCK siRNA on airway hyperreactivity reflected by acetylcholine-induced APTI. (B) Effects of nmMLCK siRNA on BAL protein leakage. (C–E) Effects of nmMLCK expression on inflammatory leukocyte infiltration (macrophage, eosinophil, and neutrophil). *P < 0.05 compared with control siRNA–PBS group; **P < 0.05 compared with control siRNA–OVA group; n = 5 or 6.