Table 1:

Effect of Inhibitors on Relaxation to Rosiglitazone in Mouse Small Airways^*

Inhibitor	Target	n	% Relaxation
			+ Inhibitor	+ Inhibitor + RGZ
Control		4	—	86.1 ± 1.1
SQ22536 (100 μM)	Adenylate cyclase	4	7.3 ± 8.4	79.7 ± 7.7
ODQ (10 μM)	Soluble guanylate cyclase	5	8.9 ± 4.2	63.9 ± 16.0
INDO (10 μM)	Cyclooxygenase (nonselective)	3	9.7 ± 10.5	79.1 ± 0.7
NOLA (100 μM)	Nitric oxide synthase	3	−2.4 ± 4.0	68.8 ± 13.2
TEA (1 mM)	K+ channels (nonselective)	4	42.3 ± 6.6†	90.9 ± 3.1

Definition of abbreviations: INDO, indomethacin; NOLA, Nω-nitro-L-arginine; ODQ, 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one; RGZ, rosiglitazone; TEA, tetraethylammonium.

^*Airways in lung slices were continuously perfused with 300 nM methacholine to elicit a precontraction before addition of inhibitor alone followed by inhibitor and 100 μM RGZ. Responses (mean ± SEM) are expressed as % relaxation of the submaximal precontraction averaged over the last minute of perfusion as described in Materials and Methods.

^†P < 0.05 (paired t test methacholine precontraction alone).