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. 2014 Mar;50(3):637–646. doi: 10.1165/rcmb.2013-0199OC

Figure 6.

Figure 6.

Spatial expression patterns of 5-HT and CGRP receptors are different in normal versus COPD lungs. (A) Representative photomicrographs of immunostaining for HTR1F (green). Staining is enriched in basal cells in normal and COPD lungs (basal cells marked with the p63 marker, red nuclei). Note that the morphology of COPD basal cells is elongated, and the distribution of the receptor uniform, compared with those in normal lungs. (B) Representative photomicrographs of immunostaining for CALCR (green). Staining is highly enriched in basal cells (marked by p63, red nuclei) and smooth muscle or neuronal fibers (white arrow) in normal donors. However, expression is lower and more diffused in COPD lungs. (C) Representative photomicrographs of immunostaining for HTR2B (green). Receptor is enriched basal cells of lungs from non-COPD subjects when compared with normal lungs. Note that in lungs of subjects with COPD, staining for HTR2B is more diffused and higher in nonbasal epithelial cells relative to basal cells (white arrow). Scale bars, 50 μm.