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. 2014 Mar;50(3):559–570. doi: 10.1165/rcmb.2013-0258OC

Figure 7.

Figure 7.

AZD-0530 treatment prevents cigarette smoke–induced MMP-9, MMP-12, and IL-17 in mice. A/J mice were exposed to 2 months of cigarette smoke or room air in combination with daily oral administration of vehicle or AZD-0530. Bronchoalveolar lavage fluid from mice was examined for MMP-9 and MMP-12 levels (A) and IL-17 BAL levels (B). (C) Quantitative PCR for mouse TNF-α, MCP-1, KC, cathepsin K, and MMP-12 was conducted using cDNA prepared from mRNA isolated from the lungs of each group. (D) Alveolar macrophages were isolated from animals exposed to cigarette smoke for 4 days and treated with AZD-0530. MMP-9 and MMP-12 levels were determined by quantitative PCR. Graphs are represented as mean ± SEM of 10 samples. P values are shown comparing both treatments connected by a line. RQ, relative quantity.