Figure 3.

Gross abnormalities in the CF ferret lung. Lungs from three CF ferrets and one non-CF ferret ranging from 3 to 8 months of age are shown. (A–C) Mucus obstruction of airways in a CF animal. Inset in (A) shows mucus accumulation in the trachea, (B) shows air-trapping (arrows) in a lobe, and (C) shows mucus accumulation in an intralobar airway. (D and E) Airway mucus from this CF animal contained numerous neutrophils, bacterial colonies (E, arrow), and neutrophil extracellular traps. (F and G) A second example of a CF lung with (F) mucus accumulation in the trachea and (G) infection with hemorrhage (*) in various lobes demonstrating interstitial pneumonia. (H) A third example of a CF lung with hemorrhage and cranial bronchopneumonia (*). (I) Gross image of a control non-CF lung. Scale bars, 100 μm (D), 25 μm (E).