Table 1:
Summary of Cystic Fibrosis Animals Evaluated and Disease States
| CF Ferret ID | Sex | Life Span (d) | Duration of Antibiotics | Lung Disease Histopathology | Mean CFU/mg Lung Protein |
|---|---|---|---|---|---|
| CF-1 | M | 257 | 6 mo | AO, MA, AI, AR, AT, SMGD | 3.1 x 107 |
| CF-2* | F | 359 | 6 mo | SMGD | 1 x 101 |
| CF-3 | F | 120 | OTD | MA, SMGD, IP (diffuse) | 2.3 x 108 |
| CF-4 | F | 100 | OTD | SMGD, IP (multifocal) | 9.2 x 103 |
| CF-5 | F | 94 | OTD | MA, SMGD, AO, AI, AT, SMGD, BP | 2.0 x 107 |
| CF-6 | M | 253 | 6 mo | AO, AI, AT, SMGD, BP | 1.2 x 104 |
| CF-7† | F | 35 | OTD | None | 3.8 x 105 |
| CF-8† | F | 32 | OTD | MA | 8.3 x 105 |
| CF-9 | F | 22 | OTD | IP | 4.8 x 104 |
| CF-10 | M | 40 | OTD | AI, SMGD | 1.7 x 105 |
| CF-11 | F | 104 | OTD | AI, SMGD | 2.0 x 103 |
Definition of abbreviations: AI, airway inflammation; AO, airway obstruction; AR, air trapping; AT, atelectasis; BP, bronchopneumonia; CF, cystic fibrosis; IP, interstitial pneumonia; MA, mucus accumulation; OTD, on antibiotics till death; SMGD, submucosal gland dilation.
*
Animal died due to the effects of estrus-associated aplastic anemia.
†
Animals were killed due to a rectal prolapse.