Table 2. Ontological categories overexpressed in suspended keratinocytes.
a) Cell adhesion | b) Positive regulators of motility |
ADAM metallopeptidase domain 9 | ADAM metallopeptidase domain 9 |
CD44 | SMAD family member 3 |
LIM and senescent cell antigen-like domains 1 | SP100 nuclear antigen |
actinin, alpha 1 | actinin, alpha 1 |
catenin, beta 1, 88 kDa | actinin, alpha 4 |
collagen, type XVII, alpha 1 | cAMP responsive element binding protein 3 |
connective tissue growth factor | cadherin 13, H-cadherin (heart) |
fibronectin 1 | chloride intracellular channel 4 |
integrin beta 1 binding protein 1 | coagulation factor II (thrombin) receptor |
integrin, alpha 2 | coagulation factor II (thrombin) receptor-like 1 |
integrin, alpha 3 | coagulation factor III (thromboplastin) |
integrin, alpha 6 | epidermal growth factor receptor |
integrin, alpha V | histone deacetylase 9 |
integrin, beta 1 | insulin receptor substrate 1 |
integrin, beta 4 | insulin-like growth factor 1 receptor |
integrin, beta 5 | integrin, alpha 2 |
integrin, beta 6 | integrin-linked kinase |
integrin-linked kinase | gp130, oncostatin M receptor |
laminin, alpha 5 | jagged 1 |
laminin, beta 1 | jagged 2 |
laminin, gamma 1 (formerly LAMB2) | laminin, alpha 3 |
nidogen 1 | laminin, alpha 5 |
polycystic kidney disease 2 | laminin, beta 1 |
protein tyrosine phosphatase, receptor type, K | matrix metallopeptidase 9 |
sarcoglycan, epsilon | mitogen-activated protein kinase kinase 1 |
thyroid hormone receptor interactor 6 | neurofibromin 2 (merlin) |
platelet-derived growth factor alpha polypeptide | |
podoplanin | |
protein tyrosine phosphatase, receptor type, K | |
related RAS (r-ras) oncogene | |
related RAS (r-ras) oncogene2 | |
reticulon 4 | |
scavenger receptor class B, member 1 | |
serpin peptidase inhibitor, clade E (nexin) | |
thrombospondin 1 | |
thyroid hormone receptor interactor 6 | |
transforming growth factor, beta 1 | |
tropomyosin 1 (alpha) | |
v-akt oncogene homolog 1 | |
vascular endothelial growth factor C | |
vinculin |
a) Cell adhesion proteins. Note the many integrins in this category. b) Positive regulators of cell motility. Note the components of the extracellular matrix and basement membrane.