Table 3. Metaanalysis comparing the ontological categories overexpressed by inducers of keratinocyte differentiation.

Category cluster	GO Category	Suspended	Suprabasal	SP600125	Confluent	Conf-EGF
Cornification	∼ectoderm development	3.E-16	5.E-03	7.E-08	3.E-34	1.E-27
	∼epidermis development	3.E-15	2.E-03	1.E-07	9.E-33	1.E-28
	∼epidermal cell differentiation	2.E-12	1.E-02	7.E-04	4.E-29	1.E-21
	∼cornified envelope	4.E-13	2.E-04	2.E-04	1.E-23	1.E-16
Innate immunity	∼response to bacterium	1.E-03		8.E-03	5.E-02	7.E-02
	∼response to molecule of bacterial origin	8.E-03		1.E-03
	∼response to lipopolysaccharide	1.E-02		4.E-03
	∼inflammatory response	4.E-02		4.E-02
Lipid metabolism	∼fatty acid metabolic process	3.E-02	4.E-03	3.E-02	5.E-02	8.E-02
	∼cellular lipid catabolic process	1.E-02		3.E-02	1.E-01	9.E-02
	∼lipid localization	4.E-03			1.E-02	6.E-02
	∼lipid transport	4.E-03			2.E-02	7.E-02
Cholesterol metab.	∼sterol biosynthetic process	9.E-02	3.E-03	2.E-03
	∼steroid metabolic process	2.E-02	5.E-03	7.E-03
	∼sterol metabolic process	6.E-02	3.E-03	3.E-02
	∼response to steroid hormone stimulus	1.E-03		7.E-03
Apoptosis	∼regulation of apoptosis	1.E-03	6.E-02	2.E-09		2.E-02
	∼regulation of programmed cell death	2.E-03	7.E-02	1.E-09		3.E-02
	∼regulation of cell death	2.E-03	7.E-02	2.E-09		3.E-02
	∼positive regulation of apoptosis	3.E-03		2.E-07
Organelles	∼membrane-enclosed lumen	9.E-03	2.E-04	2.E-19
	∼intracellular organelle lumen	6.E-03	6.E-04	2.E-19
	∼organelle lumen	8.E-03	3.E-04	4.E-19
	∼vacuole	8.E-06	5.E-04	8.E-03		6.E-03
Transcription	∼regulation of transcription RNA pol II promoter	1.E-08		2.E-10
	∼transcription factor binding	2.E-06		1.E-11
	∼chromatin	5.E-09		2.E-08
	∼regulation of nucleoside, nucleotide metabolism	1.E-09		4.E-07
Proteolysis	∼endopeptidase inhibitor activity	5.E-02	7.E-03	5.E-02	3.E-08	2.E-05
	∼peptidase inhibitor activity	7.E-02	1.E-02	8.E-02	6.E-08	4.E-05
	∼serine-type endopeptidase activity	2.E-02			7.E-08	1.E-05
	∼serine-type peptidase activity	1.E-02			2.E-07	2.E-05
Protein kinase	∼phosphorylation	7.E-06	4.E-02	5.E-06
	∼protein amino acid phosphorylation	1.E-05		5.E-05
	∼protein kinase activity	2.E-05		9.E-03
	∼protein serine/threonine kinase activity	1.E-04		2.E-02
Protein phosphatase	∼protein amino acid dephosphorylation	5.E-03	5.E-02
	∼phosphoprotein phosphatase activity	1.E-02	2.E-02
	∼phosphatase activity	9.E-03	3.E-02
	∼dephosphorylation	8.E-03	6.E-02
Cell proliferation	∼regulation of cell proliferation	3.E-04		1.E-10
	∼negative regulation of cell proliferation	7.E-05		3.E-07
	∼regulation of cell cycle	3.E-04		1.E-02
	∼negative regulation of growth	2.E-02		6.E-02
Cell motility	∼cell motion	2.E-03		3.E-04
	∼cell migration	9.E-04		6.E-04
	∼cell motility	2.E-03		2.E-03
	∼localization of cell	2.E-03		2.E-03
Nucleus	∼nuclear lumen	9.E-04	2.E-03	1.E-20
	∼nucleoplasm	6.E-03	3.E-03	3.E-15
	∼nucleoplasm part	1.E-02	2.E-02	1.E-11
	∼nucleolus	9.E-02	5.E-02	3.E-07
Oxigen response	∼response to oxidative stress	6.E-03		2.E-04	8.E-02	2.E-02
	∼response to reactive oxygen species	3.E-02		3.E-04	9.E-02	4.E-02
	∼response to hydrogen peroxide	5.E-02		2.E-04
	∼response to hypoxia	5.E-03	6.E-02	5.E-02

The p-values for each category are given for suspended, suprabasal, SP600125 JNK inhibitor treated and confluent keratinocytes in the absence or presence of EGF are given. Gray fields indicate that the given category did not reach statistical significance.