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. 2014 Jun 24;9(6):e100286. doi: 10.1371/journal.pone.0100286

Figure 3. Effect of urate on H2O2-induced cell damage in SH-SY5Y and MES23.5 cells.

Figure 3

(a, c) Concentration-dependent toxicity of H2O2 treatment for 12 h to SH-SY5Y (a) and MES23.5 cells (c). (b, d) Cells were pretreated with urate (25, 50, 100, 200 and 400 µmol/l) for 24 h, followed by H2O2 treatment at the indicated concentration in SH-SY5Y (b) and MES23.5 (d) cells. The results were repeated three times. *P<0.05, **P<0.01, ***P<0.001 versus controls; #P<0.05, ##P<0.01, ###P<0.001 versus H2O2 group.