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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Gastroenterology. 2013 Aug 14;145(6):1253–61.e1-3. doi: 10.1053/j.gastro.2013.08.016

Table 3. Regions showing more suppression on 200 mg CRF-R1 antagonist during Extinction in IBS compared to HCs.

MNI coordinates (X, Y, Z), cluster- and voxel-level probability values corrected at a family wise error rate of 5%(p), Z equivalent of the t statistic for the peak voxel of the cluster (Zequiv), and the number of voxels comprising the clusters of activation (Cluster k) with in the region of interest (ROI). Abbreviations: aINS-anterior insula, HEMI-Hemisphere, L-left, mPFC-medial prefrontal cortex, R-right.

ROI HEMI cluster P cluster k VOXEL p Zequiv X Y Z
mPFC L 0.037 50 0.042 3.81 −12 48 −2
mPFC R 0.042 39 0.086 3.52 16 48 −2
Pons L 0.017 26 0.023 3.51 −10 −36 −40
Pons R 0.039 8 0.026 3.46 2 −24 −40
aINS L 0.037 16 0.032 3.52 −36 34 0
Hippocampus R 0.007 23 0.004 3.67 32 −30 −10