Table 4. Regions more activated during PLA compared to 200 mg CRF-R1 antagonist during Extinction (suppression due to drug) in IBS patients.

MNI coordinates (X, Y, Z), cluster- and voxel-level probability values corrected at a family wise error rate of 5%(p), Z equivalent of the t statistic for the peak voxel of the cluster (Z_equiv), and the number of voxels comprising the clusters of activation (Cluster K) with in the region of interest (ROI). Abbreviations: aINS-anterior insula, HEMI-Hemisphere, L-left, mPFC-medial prefrontal cortex, pACC-pregenual anterior cingulate cortex, R-right.

ROI	HEMI	Cluster P	Cluster k	Voxel P	Zequiv	X	Y	Z
mPFC/pACC	L	0.018	75	0.025	3.97	−16	48	0
mPFC/pACC	R	0.039	42	0.099	3.47	14	52	−2
Hippocampus	L	0.010	15	0.004	3.74	−32	−32	−8
Hippocampus	R	0.002	70	0.000	4.62	36	−22	−10
Midbrain	L	0.014	35	0.007	3.89	−14	−20	−2
Midbrain	R	0.014	36	0.019	3.60	16	−22	−2
Pons	L	0.001	156	0.002	4.28	−14	−42	−40
Pons	R	0.011	40	0.016	3.63	4	−26	−38
Pons	R	0.057	2	0.057	3.19	16	−40	−38
Thalamus	L	0.004	76	0.005	3.97	−14	−20	0
Thalamus	R	0.003	86	0.010	3.74	18	−20	0
aINS	R	0.010	51	0.029	3.50	34	16	−4