Table 4. Minimal deleted or gained regions found in APL series, their frequency and the genes included in each region.

Minimal deleted region (MDR)	Proximal	Distal	Size (Mb)	Akagi et al. (n = 47)	TCGA (n = 20)	Nowak et al. (n = 93)	This Report (n = 48)	Total n = 208	Genes
del(6p25.1–24.3)	5600438	7409514	1,81	1 (2%)	0	0	2 (4%)	3 (1%)	FARS2, NRN1, F13A1, LY86, RREB1, CAGE1.
del(6p24.1)	12278913	13386241	1,11	0	0	1 (1%)	1 (1%)	2 (1%)	EDN1, PHACTR1, TBC1D7, GF0D1.
del(7q33-qter)	137199691	158861884	21,66	1 (2%)	1 (5%)	5 (5%)	3 (6%)	10 (5%)	several genes including LUC7L2, EZH2.
del/UPD(11p14)	22936456	30671304	7,73	3 (6%)	1 (5%)	0	1 (1%)	5 (2%)	LUZP2, ANO3, MUC15, SLC5A12, BBPX1, CCDC34, LGR4, LIN7C, BDNF, METTL15, KCNA4, FSHB, MPPED2.
del(12p13.33)	1027361	1134264	0,11	0	0	0	2 (4%)	2 (1%)	RAD52, ERC1.
del(15q24.1)	74691249	75117832	0,43	0	0	1 (1%)	1 (1%)	2 (1%)	SEMA7A, UBL7, ARID3B, CLK3, EDC3, CYP1A1, CSK, LMAN1L.
del(17pter-p11.2)	0	18935523	18,94	1 (2%)	0	3 (3%)	1 (1%)	5 (2%)	several genes including TP53.
del(17q12)	37959105	38079219	0,12	0	0	1 (1%)	1 (1%)	2 (1%)	IKZF3, GSDMB, ZPBP2, ORMDL3.
Minimal gained region (MGR)
dup(4q27–q31.23)	123059206	150420462	27,36	0	0	5 (5%)	1 (1%)	6 (3%)	several genes.
dup(8q24)	122538604	132023578	9,48	8 (17%)	2 (10%)	23 (25%)	11 (23%)	44 (21%)	several genes including MYC.
dup(13q31.1–q34)	85060629	115108397	30,05	1 (2%)	0	1 (1%)	2 (4%)	4 (2%)	several genes.
dup(15q24.1) intra PML	74262253	74304138	0,04	0	0	4 (4%)	2 (4%)	6 (3%)	PML.
dup(15q24.1–q26.3)	74326556	102364660	28,04	2 (4%)	0	3 (3%)	1 (1%)	6 (3%)	several genes including PML.
dup(17q21.2) intra RARA	38505591	38673928	0,17	0	0	1 (1%)	1 (1%)	2 (1%)	RARA.
dup(17p11.2–q21.2)	21550542	38477259	16,93	1 (2%)	0	3 (3%)	1 (1%)	5 (2%)	several genes including NF1, RARA
dup(21q22)	39661746	39772776	0,11	2 (4%)	0	1 (1%)	1 (1%)	5 (2%)	KCNJ15, ERC.