Table 3.
Probabilistic sensitivity analysis parameter (range and distribution)
| Range
|
Distribution | Reference | ||
|---|---|---|---|---|
| Min | Max | |||
| Epidemiological and efficacy parameter | ||||
| Prevalence rate: male | 2.0% | 3.5% | BETA | 17,18 |
| Prevalence rate: female | 2.0% | 3.5% | BETA | 17,18 |
| Incidence rate | 0.010% | 0.020% | BETA | |
| SVR base-case G1/G4 | 24.0% | 37.0% | BETA | 23–26 |
| SVR base-case G2/G3 | 59.0% | 65.0% | BETA | 23–26 |
| Annual cost | ||||
| Chronic hepatitis | €231 | €346 | GAMMA | 10,31,32 |
| Compensated cirrhosis | €325 | €489 | GAMMA | 10,31,32 |
| Decompensated cirrhosis | €5,125 | €7,691 | GAMMA | 10,31,32 |
| Carcinoma | €5,699 | €8,548 | GAMMA | 10,31,32 |
| Transplantation (surgery) | €72,175 | €88,221 | GAMMA | 30 |
| Transplantation (1st year treatment) | €3,784 | €5,675 | GAMMA | 10,31,32 |
Abbreviations: G, genotype; SVR, sustained virological response; Min, minimum; Max, maximum.