. Author manuscript; available in PMC: 2014 Sep 1.

Published in final edited form as: Pain. 2013 Jun 6;154(9):1856–1864. doi: 10.1016/j.pain.2013.06.002

Table 6.

Summary of significance of direct and indirect (mediated) effects for model in which the association between placebo condition evoked pain sensitivity and morphine analgesic responsiveness is mediated by EO function.

		Indirect Effect via EO Function
			Bootstrap 95% Confidence Intervals
Evoked Pain Measure	Direct Effect	Sobel Test	Lower	Upper
ISC Tolerance	p=002	p=.007	−0.27	−0.04^*
ISC NRS	n.s.	p=.041	0.01	0.17^*
ISC VAS Intensity	p=037	p=.032	0.02	0.30^*
Thermal Threshold	p=.027	p=051	−0.14	−0.02^*
Thermal VAS Intensity	p=.021	p=.072	−0.004	0.24

p<.05

Note: Mediation models were only tested for individual evoked pain measures demonstrating an effect to be mediated (i.e., a significant association between placebo pain responses and morphine analgesic responses).