Skip to main content
. 2014 Jun 24;9(6):e100777. doi: 10.1371/journal.pone.0100777

Figure 6. Dapagliflozin inhibits apoptosis in the kidney.

Figure 6

(A, B) Apoptosis was detected by TUNEL staining. Arrowheads indicate the apoptotic nuclei. The number of apoptotic cells was higher in the interstitia of db/db mice than in db/m mice, and was lower in the db/db+dapa groups than in the db/db group. Original magnification, ×400. Data are mean ± SEM. *P<0.05. (C, D) Dapagliflozin reduced the mRNA levels of Caspase-12 and Bax in the kidney. mRNA levels were normalized against Atp5f1 expression. Data are mean ± SEM. *P<0.05.