Table 1. Influence of dapagliflozin on physiologic and metabolic parameters in db/db and db/m mice at 20 weeks.

	db/m	db/db	db/db+0.1 dapa	db/db+1.0 dapa
Systolic blood pressure (mmHg)	120.0±5.2	116.6±4.5	121.2±2.3	115.2±4.5
Diastolic blood pressure (mmHg)	79.4±3.2	78.8±2.3	86.3±1.6	84.3±3.0
HbA1c (%)	4.0±0.1	9.2±0.2a	8.5±0.3a	6.6±0.2abc
Water intake (ml/day)	4.8±0.4	31.1±4.1a	22.3±2.9a	19.8±1.9a
Food intake (g/day)	3.2±0.1	4.5±0.7	4.8±0.3	6.1±0.3a

db/m, nondiabetic control mice; db/db, untreated diabetic mice; db/db+0.1 dapa, dapagliflozin (0.1 mg/kg)-treated diabetic mice; db/db+1.0 dapa, dapagliflozin (1.0 mg/kg)-treated diabetic mice; HbA1c, hemoglobin A1c. Data are presented as mean ± SEM;

^a P<0.05 vs. db/m,

^b P<0.05 vs. db/db,

^c P<0.05 vs. db/db+0.1 dapa.