Table 2. Influence of dapagliflozin on renal structural and functional parameters at 20 weeks.

	db/m	db/db	db/db+0.1 dapa	db/db+1.0 dapa
Kidney weight (mg)	379.0±39.6	247.0±6.8a	239±9.4a	252.5±9.1a
Relative kidney weight (mg/g body weight)	11.5±1.0	6.0±0.3a	5.2±0.4a	4.5±0.1a
BUN (mg/dl)	20.3±0.7	29.1±2.8	24.6±2.5	25.9±0.6
Serum creatinine (mg/dl)	0.10±0.01	0.12±0.02	010±0.01	0.12±0.02
Urine volume (ml/day)	1.0±0.1	23.4±3.1a	19.2±2.4a	16.3±1.9a
Ccr (ml/min)	4.80±0.54	9.42±0.96a	9.81±0.78a	6.40±0.65c

db/m, nondiabetic control mice; db/db, untreated diabetic mice; db/db+0.1 dapa, dapagliflozin (0.1 mg/kg)-treated diabetic mice; db/db+1.0 dapa, dapagliflozin (1.0 mg/kg)-treated diabetic mice; BUN, blood urea nitrogen; Ccr, creatinine clearance. Data are presented as mean ± SEM;

^a P<0.05 vs. db/m,

^b P<0.05 vs. db/db,

^c P<0.05 vs. db/db+0.1 dapa.