Table 2. Network statistics of M9 and M12 RA CD4+ gene expression modules.
Module | Gene Symbol | BC | DC | Module | Gene Symbol | DC | BC |
M9 | IL4 | 0.5329 | 5 | M9 | IL4 | 5 | 0.5329 |
M9 | MS4A2 | 0.4395 | 3 | M9 | CCR3 | 5 | 0.3297 |
M9 | CCR3 | 0.3297 | 5 | M9 | IL8 | 5 | 0.3021 |
M9 | IL8 | 0.3021 | 5 | M9 | MS4A2 | 3 | 0.4395 |
M9 | FCER1A | 0.2637 | 3 | M9 | FCER1A | 3 | 0.2637 |
M9 | NAMPT | 0.1429 | 2 | M9 | CCR2 | 3 | 0.0549 |
M9 | GAB2 | 0.1429 | 2 | M9 | NAMPT | 2 | 0.1429 |
M9 | CCR2 | 0.0549 | 3 | M9 | GAB2 | 2 | 0.1429 |
M9 | CCL3L1 | 0.0110 | 2 | M9 | CCL3L1 | 2 | 0.0110 |
M9 | RGS18 | 0.0000 | 1 | M9 | POLE | 2 | 0.0000 |
M12 | TSPO | 0.2436 | 55 | M12 | CDK1 | 57 | 0.1717 |
M12 | CDK1 | 0.1717 | 57 | M12 | TSPO | 55 | 0.2436 |
M12 | RPS3 | 0.0905 | 11 | M12 | BIRC5 | 53 | 0.0432 |
M12 | TYROBP | 0.0836 | 35 | M12 | CDC45 | 51 | 0.0138 |
M12 | CD4 | 0.0738 | 36 | M12 | KIAA0101 | 50 | 0.0515 |
M12 | KIAA0101 | 0.0515 | 50 | M12 | TOP2A | 50 | 0.0156 |
M12 | MNDA | 0.0472 | 20 | M12 | CCNA2 | 50 | 0.0036 |
M12 | MAPK1 | 0.0455 | 25 | M12 | TK1 | 49 | 0.0246 |
M12 | BIRC5 | 0.0432 | 53 | M12 | CDT1 | 49 | 0.0156 |
M12 | ITGAM | 0.0425 | 34 | M12 | DLGAP5 | 49 | 0.0103 |
Applying the new systems genetics approach for trans-eQTL identification in RA CD4+ T cells, the BC and DC values were computed for each particular gene of M9 and M12 immunity-enriched modules. On the left side of the table, the top 10 genes showing the highest BC values in each module are sorted by BC in decreasing order. On the right side of the table, the top 10 genes showing the highest DC values in each module are sorted by DC in decreasing order.
Abbreviations: BC, Betweenness centrality; DC, Degree centrality.