Table 2. Network statistics of M9 and M12 RA CD4+ gene expression modules.

Module	Gene Symbol	BC	DC	Module	Gene Symbol	DC	BC
M9	IL4	0.5329	5	M9	IL4	5	0.5329
M9	MS4A2	0.4395	3	M9	CCR3	5	0.3297
M9	CCR3	0.3297	5	M9	IL8	5	0.3021
M9	IL8	0.3021	5	M9	MS4A2	3	0.4395
M9	FCER1A	0.2637	3	M9	FCER1A	3	0.2637
M9	NAMPT	0.1429	2	M9	CCR2	3	0.0549
M9	GAB2	0.1429	2	M9	NAMPT	2	0.1429
M9	CCR2	0.0549	3	M9	GAB2	2	0.1429
M9	CCL3L1	0.0110	2	M9	CCL3L1	2	0.0110
M9	RGS18	0.0000	1	M9	POLE	2	0.0000
M12	TSPO	0.2436	55	M12	CDK1	57	0.1717
M12	CDK1	0.1717	57	M12	TSPO	55	0.2436
M12	RPS3	0.0905	11	M12	BIRC5	53	0.0432
M12	TYROBP	0.0836	35	M12	CDC45	51	0.0138
M12	CD4	0.0738	36	M12	KIAA0101	50	0.0515
M12	KIAA0101	0.0515	50	M12	TOP2A	50	0.0156
M12	MNDA	0.0472	20	M12	CCNA2	50	0.0036
M12	MAPK1	0.0455	25	M12	TK1	49	0.0246
M12	BIRC5	0.0432	53	M12	CDT1	49	0.0156
M12	ITGAM	0.0425	34	M12	DLGAP5	49	0.0103

Applying the new systems genetics approach for trans-eQTL identification in RA CD4+ T cells, the BC and DC values were computed for each particular gene of M9 and M12 immunity-enriched modules. On the left side of the table, the top 10 genes showing the highest BC values in each module are sorted by BC in decreasing order. On the right side of the table, the top 10 genes showing the highest DC values in each module are sorted by DC in decreasing order.

Abbreviations: BC, Betweenness centrality; DC, Degree centrality.