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. 2014 Jun 24;9(6):e100690. doi: 10.1371/journal.pone.0100690

Table 3. Trans-eQTL associations revealed by the application of the systems genetics approach.

Module SNP Gene SNP Coordinates (bp) Gene Coordinates (bp) β P-value PFDR
M9 rs9293162 FCER1A chr5:25065470 chr1:159253678–159278014 1,851 1.1927e-07 0.077
M9 rs978897 FCER1A chr7:15598156 chr1:159253678–159278014 1,670 3.2865e-07 0.094
M12 rs3862556 KIAA0101 chr10:76540987 chr15:64657210–64673702 −0,924 2.4332e-08 0.046*
M12 rs711114 KIAA0101 chr12:78003541 chr15:64657210–64673702 −0,848 5.0807e-08 0.048*
M12 rs10283761 BIRC5 chr9:26755930 chr17:76210276–76221716 −0,345 5.3493e-08 0.048*
M12 rs9561023 KIAA0101 chr13:93022401 chr15:64657210–64673702 −0,999 6.0208e-08 0.048*
M12 rs2513046 KIAA0101 chr11:62236094 chr15:64657210–64673702 −0,999 6.0208e-08 0.048*
M12 rs17009383 KIAA0101 chr3:21771769 chr15:64657210–64673702 −0,573 7.3813e-08 0.048*
M12 rs4806933 KIAA0101 chr19:3414020 chr15:64657210–64673702 −0,727 1.6853e-07 0.079
M12 rs4745758 KIAA0101 chr10:76568257 chr15:64657210–64673702 −0,814 4.7989e-07 0.095
M12 rs11001178 KIAA0101 chr10:76601805 chr15:64657210–64673702 −0,814 4.7989e-07 0.095
M12 rs10824245 KIAA0101 chr10:76666799 chr15:64657210–64673702 −0,814 4.7989e-07 0.095
M12 rs736086 KIAA0101 chr10:76683785 chr15:64657210–64673702 −0,814 4.7989e-07 0.095
M12 rs4746248 KIAA0101 chr10:76705881 chr15:64657210–64673702 −0,814 4.7989e-07 0.095
M12 rs7046685 KIAA0101 chr9:28659143 chr15:64657210–64673702 −0,873 5.0499e-07 0.095
M12 rs12341535 KIAA0101 chr9:28663042 chr15:64657210–64673702 −0,873 5.0499e-07 0.095
M12 rs17101861 KIAA0101 chr14:34232772 chr15:64657210–64673702 −0,873 5.0499e-07 0.095
M12 rs6756606 CDK1 chr2:178700057 chr10:62538211–62554610 −0,688 5.2009e-07 0.095
M12 rs10497482 CDK1 chr2:178805428 chr10:62538211–62554610 −0,688 5.2009e-07 0.095
M12 rs6756606 KIAA0101 chr2:178700057 chr15:64657210–64673702 −0,955 5.5269e-07 0.095
M12 rs10497482 KIAA0101 chr2:178805428 chr15:64657210–64673702 −0,955 5.5269e-07 0.095
M12 rs2714384 BIRC5 chr18:25302948 chr17:76210276–76221716 −0,348 6.4318e-07 0.098
M12 rs2617950 BIRC5 chr18:25309414 chr17:76210276–76221716 −0,348 6.4318e-07 0.098
M12 rs2851757 BIRC5 chr18:25313101 chr17:76210276–76221716 −0,348 6.4318e-07 0.098

Applying the new systems genetics approach for trans-eQTL identification in RA CD4+ T cells, the associations obtained after performing the trans-eQTL analysis are displayed for each immunity-enriched module (PFDR<0.01).

Abbreviations: Bp, Base pair; β, Slope coefficient; PFDR, P-value False Discovery Rate.

* Significant (PFDR<0.05).