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. 2014 Jun 18;9:2993–3003. doi: 10.2147/IJN.S61103

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© 2014 Yao et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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(A) Transmission electron micrographs of CSO-SA and CA-CSO-SA micelles. (B) Transmission electron micrographs of CSO-SA/pDNA and CA-CSO-SA/pDNA nanoparticles (at a weight ratio of 5). (C) Gel retardation analyses of CSO-SA/pDNA and CA-CSO-SA/pDNA nanocomplexes, where lanes 1–6 show weight ratios of 0, 0.2, 0.5, 1, 2, and 5, respectively. (D) DNase I protection assay, where lanes 1–6 represent naked pDNA, naked pDNA + DNase I, CSO-SA/pDNA, CSO-SA/pDNA + DNase I, CA-CSO-SA/pDNA, and CA-CSO-SA/pDNA + DNase I, respectively.

Notes: CSO-SA/pDNA and CA-CSO-SA/pDNA nanocomplexes prepared at a weight ratio of 2.5. After inactivation by DNase, heparin was added to disassemble the polyplexes.

Abbreviations: CA, cis-aconitate; SA, stearic acid; CSO, chitosan oligosaccharide; pDNA, plasmid DNA; w/w, weight ratio.