Figure 2. Intradermal PHA and LPS responses in miniature pigs exposed to SPE-like radiation.

Local reaction to intradermal PBS, PHA, and LPS injections were measured 48(n = 3) (A) showed a statistically significant increase in the diameter of response to PHA compared to pre-irradiation. As a similar response to radiation was found at each dose, animals receiving all amounts of electron radiation (5, 7.5, 10, 12.5, 15 and 25 Gy, 3 per dose) were combined for analysis. The response to stimulation with PBS (B), PHA (C), and LPS (D) were measured as the diameter of induration, erythema, and ulceration and averages ± SEM are presented. Statistical significance compared to pretreatment values was determined by Student’s t-test, using Bonferroni’s correction for multiple comparisons, * = p<0.017.