Table 4.

Multivariable-adjusted^a linear regression coefficients (β) for the association of log-transformed IL-6, TNF-α and CRP with BMD of the hip and spine among post-menopausal women of the Framingham Offspring cohort.

	Neck		Trochanter		Total Femur		Lumbar spine
	β b	P-value	β	P-value	β	P-value	β	P-value
Using menopausal hormone therapy
IL-6 (pg/mL)	0.011	0.20	0.009	0.25	0.010	0.24	0.010	0.43
TNF-α (pg/mL)	−0.005	0.69	−0.004	0.74	−0.008	0.50	−0.025	0.20
CRP (mg/L)	0.011	0.04	0.007	0.16	0.009	0.10	0.008	0.35
Not using menopausal hormone therapy
IL-6 (pg/mL)	−0.007	0.22	−0.009	0.10	−0.007	0.27	−0.005	0.55
TNF-α (pg/mL)	−0.008	0.38	0.001	0.89	−0.005	0.61	−0.006	0.64
CRP (mg/L)	0.004	0.28	0.002	0.56	0.004	0.28	0.006	0.30

^aModels adjusted for age, BMI, height, physical activity (PASE) and smoking

^bDifference in BMD for each 1 unit increase in log-transformed IL-6, TNF-α or CRP