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. Author manuscript; available in PMC: 2015 Feb 28.
Published in final edited form as: Differentiation. 2014 Feb 28;87(0):4–22. doi: 10.1016/j.diff.2013.12.003

Figure 6.

Figure 6

Three-dimensional reconstructions (3DR) (A, E & F) as well as sections (BD) of an adult male hyena penis exposed prenatally to flutamide (25mg/kg/day) from 32 to 110 days of gestation. (A) Side view with the skin (tan) semi-transparent to reveal internal structures. Note color-coding of labels throughout the figure. Prenatal flutamide has elicited the female pattern of the urethral orifice opening onto the surface ventral to the tip of the penis. (B) Distal section demonstrating the urethra (black arrowheads) opening ventrally. Large white arrow pointing to 3DR (B) indicates the position of section (A). (C) Section through the glanular erectile body (green in A & E) as indicated by the tip of the large white arrow pointing to 3DR (A). Note glanular erectile body (dotted lines), tunica (black arrowheads) only surrounding the corporal body (CB). The urethra (Ur) is large, pleated and ventrally positioned. (D) Proximal section through the retractor muscles (blue in A & F) as indicated by the tip of the large white arrow pointing to 3DR (A). Retractor muscles (dotted lines) are dorsal to the urethra (UR). The tunica (arrowheads) surrounds the corporal body (CB) only. (E) ¾ side view of proximal end of penis of a prenatally flutamide-treated adult male hyena. The arrangement of structures of this male specimen exhibits the female pattern (compare with Fig. 5C).