Fig. 1.

 Schematic representation of electrochemotherapy: Phase 1: Injection of the cytostatic: bleomycin (i. v./intratumoural) or cisplatin (intratumoural); Phase 2: high-frequency electroporation results in a permeable cell membrane and the cytostatic agent reaches up to 10 000 times higher concentrations in the tumour cell; Phase 3: reversible poration, the cell membrane closes and the cytostatic drug accumulates in the tumour cell (courtesy of IGEA, Carpi, Italy).