Table 3.

Association of KIM-1, IL-18, and ACR with incident heart failure, stratified by race

	White*	Black*
KIM-1:Cr
Q1: <497 pg/mg	1.00 (reference)	1.00 (reference)
Q2: 497–814 pg/mg	1.29 (0.87, 1.90)	0.90 (0.63, 1.26)
Q3: 815–1239 pg/mg	1.36 (0.95, 1.96)	1.30 (0.89, 1.89)
Q4: ≥1240 pg/mg	1.47 (1.04, 2.09)	1.62 (1.09, 2.40)
IL-18:Cr
Q1: <19 pg/mg	1.00 (reference)	1.00 (reference)
Q2: 19–31 pg/mg	1.03 (0.74, 1.42)	1.11 (0.77, 1.59)
Q3: 32–55 pg/mg	1.32 (0.95, 1.82)	1.20 (0.83, 1.74)
Q4: ≥56 pg/mg	1.42 (1.01, 2.00)	1.25 (0.85, 1.82)
ACR
Q1: <4.57 mg/g	1.00 (reference)	1.00 (reference)
Q2: 4.57–8.28 mg/g	1.07 (0.77, 1.48)	1.30 (0.83, 2.02)
Q3: 8.29–20.33 mg/g	1.46 (1.06, 2.01)	1.39 (0.90, 2.15)
Q4: ≥20.34 mg/g	1.67 (1.20, 2.32)	2.32 (1.57, 3.43)

Note: Values are multivariable-adjusted hazard ratio (95% confidence interval). Adjusted for age, gender, race, education, diabetes, hypertension, systolic blood pressure, smoking, prevalent coronary heart disease, albumin, C-reactive protein, and estimated glomerular filtration rate).

ACR, albumin-creatinine ratio; Cr, creatinine; KIM-1, kidney injury molecule 1; IL-18, interleukin 18; Q, quartile

^*P values for interaction: 0.25 [KIM-1], 0.89 [IL-18], and 0.11 [ACR])