Table 2.

Associations between heritable factors previously associated with ALL risk and age at diagnosis (in months) among Hispanic CCLS participants with B-cell ALL.

Heritable factor previously associated with ALL risk	Effect (95% CI)*	P*
%European ancestry	−5.97 (−0.36, −11.57)	0.037
%Native American ancestry	5.98 (0.37, 11.64)	0.037
rs4132601-G (IKZF1)	−1.06 (−7.68, 5.64)	0.75
rs3731217-T (CDKN2A)	4.44 (−9.12, 17.88)	0.52
rs3824662-A (GATA3)	2.59 (−3.80, 8.99)	0.52
rs7088318-A (PIP4K2A)	−0.85 (−8.04, 6.36)	0.82
rs7089424-C (ARID5B)	−2.28 (−8.88, 4.32)	0.50
rs2239633-G (CEBPE)	−2.96 (−9.34, 3.41)	0.36
Global genetic risk score (risk allele sum)	−0.56 (−3.37, 2.26)	0.70

^*Effect size (measured in months) is generated from a multivariable linear regression model where “age at diagnosis” is the dependent variable, adjusting for: sex, income, %African ancestry, hyperdiploidy, and TEL-AML1 status. Positive values indicate older age at diagnosis with an increasing number of risk alleles or with each 20% increase in % ancestry. Negative values indicate younger age at diagnosis with an increasing number of risk alleles or with each 20% increase in Native American or European ancestry. P-values are two-sided and are derived from these regression models (Ho: Beta=0).