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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Am J Hematol. 2014 Apr 18;89(7):721–725. doi: 10.1002/ajh.23727

Table 3.

Associations between somatic ALL alterations and age at diagnosis (in months) among Hispanic CCLS participants with B-cell ALL.

Somatic ALL alteration Effect (95% CI)* P*
Hyperdiploidy (51+ chromosomes) −12.4 (−21.9, −2.8) 0.011
TEL-AML1 + status −24.4 (−37.4, −11.5) 2.0 × 10−4
RAS mutation + (KRAS/NRAS) 0.76 (−12.8, 14.3) 0.91
CDKN2A (p16) deletion + 19.7 (8.4, 31.0) 7.0 × 10−4
IKZF1 deletion + 18.1 (3.9, 32.2) 0.012
PAX5 deletion + −0.38 (-13.1, 12.3) 0.95
*

Effect size (measured in months) is generated from a multivariable linear regression model where “age at diagnosis” is the dependent variable and somatic ALL alterations are modeled jointly, adjusting for: sex, income, %African ancestry and %European ancestry. Positive values indicate that the somatic alteration is associated with an older age at diagnosis. Negative values indicate that the somatic alteration is associated with a younger age at diagnosis. P-values are two-sided and are derived from this regression model (Ho: Beta=0).