Figure 1. Flow chart to illustrate separation of review between three comparisons. Six RCTs met the original entry criteria of the review. All of these had a placebo and long-acting beta-agonist arm, and five assessed combination against steroids. Seven new studies with one or more control comparisons were identified: five had a placebo arm, four had a long-acting beta-agonist arm, and two had an inhaled steroid treatment arm.