Date	Event	Description
8 April 2008	Amended	Converted to new review format.
21 August 2007	New citation required and conclusions have changed	This review contains evidence from 5 studies previously included in a review of combination therapy in COPD (Nannini L, Cates CJ, Lasserson TJ, Poole P Combined corticosteroid and long-acting beta-agonist in one inhaler for chronic obstructive pulmonary disease. Cochrane Database of Systematic Reviews 2004, Issue 3), with new data from two studies (TORCH; SFCT01). New findings There is a significant reduction on mortality with combination therapy compared with ICS alone. Exacerbation rates are lower with combination therapy compared with ICS. Additional work should focus on budesonide and formoterol, and the collection of data on pneumonia