TABLE 1.
Gene expression in the zebrafish habenulae and homology with rodents
Listed are genes found to be transcribed in regions of the dorsal (D) and/or ventral (V) habenular nuclei for larval (La) or adult (A) zebrafish, as determined by RNA in situ hybridization. Questions marks indicate where published data are unclear. Expression of homologous genes in the medial (M) and/or lateral (L) habenular nuclei of rodents is also noted. References are provided for the zebrafish and rodent studies. AB atlas signifies the Allen Mouse Brain Atlas, available from: http://mouse.brain-map.org, ©2012 Allen Institute for Brain Science.
| Zebrafish Gene Name | Gene Symbol | Zebrafish Ha Domain | Stage | Zebrafish References | Rodent Ha Domain | Rodent References |
|---|---|---|---|---|---|---|
| adenylate cyclase activating polypeptide 1a | adcyap1a | D (left only) | La | Amo et al., 2010 | M, L | AB atlas |
| amine oxidase, copper containing 1 | aoc1 | V | La, A | Amo et al., 2010 | Neither | AB atlas |
| anoctamin 2 | ano2 | D | La | This study | M | AB atlas |
| Ca2+-dependent activator protein for secretion 2 | cadps2 | D | La | Gamse et al., 2003; Chen et al., 2009 | M, L | Sadakata et al., 2007 |
| calcium/calmodulin-dependent protein kinase IGb | camk1gb | D, V? | La | Tovin et al., 2012 | Neither | AB atlas |
| cAMP responsive element binding protein 1a | creb1a | D, V | A | Dworkin et al., 2007 | Neither | AB atlas |
| cell adhesion molecule 2a | cadm2a | D (L>R), V? | La, A | Pietri et al., 2007 | M | AB atlas |
| choline acetyltransferase | chatb | D (R>L), V | La, A | Hong et al., 2013 | M | Lauterborn et al., 1993 |
| chemokine (C-X-C motif), receptor 4b | cxcr4b | D | La | Carl et al., 2007; Roussinge et al., 2009 | Neither | AB atlas |
| collapsin response mediator protein | crmp1 | D | La | Jayasena et al., 2011 | M | AB atlas |
| contactin 2 | cntn2 | D (R>L), V? | La | Carl et al., 2007 | Neither | AB atlas |
| cytochrome P450, family 19, subfamily A, polypeptide 1 | cyp19a1b | D, V | A | Goto-Kazeto et al., 2004 | L | Shinoda et al., 1989 |
| developing brain homeobox 1b | dbx1b | D, V? | La | Wu et al., 2014 | Neither | AB atlas |
| ets variant gene 1 | etv1 | D (L>R) | La | Roussinge et al., 2006 | M | Quina et al., 2009 |
| extracellular leucine-rich repeat and fibronectin type III domain containing 1b | elfn1b | D (L>R) | La | Sollner and Wright, 2009 | M, L | Dolan and Mitchell, 2013 |
| F-box protein 7 | fbxo7 | D, V | A | Zhao et al., 2012 | M | AB atlas |
| follistatin-like 4 | fstl4 | D, V? | A | Tsuchimoto et al., 2005 | Neither | AB atlas |
| G protein-coupled receptor 161 | gpr161 | D, V? | La | Leung et al., 2008 | Neither | AB atlas |
| glutamate receptor, ionotropic, AMPA 1a,b | gria1a,b | D?, V | La | Hoppmann et al., 2008 | M, L | AB atlas |
| glutamate receptor, ionotropic, AMPA 4a,b | gria4a,b | D | La | Hoppmann et al., 2008 | M, L | AB atlas |
| guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a | gnao1a | D, V? | La | Huang et al., 2012 | M | AB atlas |
| guanine nucleotide binding protein, gamma 8 | gng8 | D, V | La | This study | M | Betty et al., 1998 |
| glutamate receptor, metabotropic 3 | grm3 | D (R>L) | La | Haug et al., 2013 | M, L | Ohishi et al., 1993 |
| glutamate receptor, metabotropic 4 | grm4 | D, V? | La | Haug et al., 2013 | Neither | AB atlas |
| glutamate receptor, metabotropic 6a | grm6a | D | La | Haug et al., 2013 | Neither | AB atlas |
| glutamate receptor, metabotropic 6b | grm6b | D (R>L) | La | Haug et al., 2013 | Neither | AB atlas |
| glutamate receptor, metabotropic 7 | grm7 | D | La | Haug et al., 2013 | L | Ohishi et al., 1995 |
| glutamate receptor, metabotropic 8b | grm8b | V | La | Haug et al., 2013 | Neither | AB atlas |
| 5-hydroxytryptamine (serotonin) receptor 1bd | htr1bd | D (L>R), V? | La, A | Norton, 2008 | Neither | AB atlas |
| hypocretin receptor | hcrtr | D | La, A | Appelbaum et al., 2009 | Neither | AB atlas |
| Kallmann syndrome 1a sequence | kal1a | D, V | A | Ayari et al., 2012 | NA | |
| Kallmann syndrome 1b sequence | kal1b | D?, V | A | Ayari et al., 2012 | NA | |
| kisspeptin1 | kiss1 | V | A | Kitashi et al., 2009; Ogawa 2012 | Neither | AB atlas |
| kisspeptin1 receptor | kiss1r | V | A | Servili et al., 2011 | M | AB atlas |
| Kruppel-like factor 4a | klf4a | V | La | Li et al., 2011 | Neither | AB atlas |
| leptin receptor | lepr | D, V | A | Liu et al., 2010 | Neither | AB atlas |
| platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b | pafah1b1b | D | La | Drerup et al., 2010 | M, L | AB atlas |
| melanin-concentrating hormone receptor 1a | mchr1a | D, V | A | Berman et al., 2009 | Neither | AB atlas |
| monoamine oxidase | mao | D, V | A | Anichtchik et al., 2006 | M, L | AB atlas |
| muscleblind-like 3 (Drosophila) | mbnl3 | V | La | This study | Neither | AB atlas |
| nudE nuclear distribution gene E homolog like 1 (A. nidulans) A | ndel1a | D | La | Drerup et al., 2007 | M, L | AB atlas |
| neuropilin 1a | nrp1a | D (left only) | La | Kuan et al., 2007 | Neither | AB atlas |
| neuronal pentraxin 2a | nptx2a | D (L>R) | La, A | Agetsuma et al., 2010 | M | AB atlas |
| neuronal pentraxin 2b | nptx2b | D?, V | A | Appelbaum et al., 2010 | See nptx2a | |
| nuclear receptor subfamily, group A, member 2 | nr4a2 | D, V? | La | Blin, 2008 | M, L | Quina et al., 2009 |
| opsin 4xa | opn4xa | D | La | Matos-Cruz et al., 2011 | No homolog | |
| purkinje cell protein 4a | pcp4a | D, V | La, A | Mione et al., 2006 | M, L | AB atlas |
| PTEN induced putative kinase 1 | pink1 | D, V | A | Sallinen et al., 2010 | M, L | Taymans et al., 2006 |
| potassium channel tetramerization domain 12.1 | kctd12.1 | D (L>R) | La, A | Gamse et al., 2003 | M | Gamse et al., 2005 Metz et al., 2011 |
| potassium channel tetramerization domain 12.2 | kctd12.2 | D (R>L), V | La, A | Gamse et al., 2005 | See kctd12.1 | |
| potassium channel tetramerization domain 8 | ktcd8 | D (R>L) | La, A | Gamse et al., 2005 | M | Gamse et al., 2005 Metz et al., 2011 |
| POU domain, class 4, transcription factor 1 | pou4f1 | D (R>L) | La, A | Amo et al., 2010 | M, L | Quina et al., 2009 |
| prokineticin 2 | prok2 | D, V | A | Ayari et al., 2010 | M, L | Cheng et al., 2006 |
| protocadherin-10 | pcdh10a | V | A | Amo et al., 2010 | L | Aizawa et al., 2012 |
| purkinje cell peptide 4 | pcp4a | D, V | La, A | Mione et al., 2006 | M, L | AB atlas |
| reticulon 4 receptor | rtn4r | D, V? | La | Brösamle et al., 2009 | M | Josephson et al., 2002 |
| roundabout homolog 3 | robo3 | D, V? | La | Sollner and Wright, 2009 | M | Quina et al., 2009 |
| si:ch211-154o6.4 | D (R>L), V? | La | Amo et al., 2010 | No homolog | ||
| solute carrier family 5 (choline transporter) member 7 | slc5a7; hacta | D (R>L) | La, A | Hong et al., 2013 | M | AB atlas |
| solute carrier family 18 (vesicular acetylcholine), member 3b | slc18a3; vachtb | D (R>L), V | La, A | Hong et al. 2013 | M | Quina et al., 2009 |
| solute carrier family17 (sodium- dependent inorganic phosphate cotransporter), member 6a | slc17a6; vglut2b | D, V | La, A | Appelbaum 2009 | M, V | Aizawa et al., 2012 |
| solute carrier family17 (sodium- dependent inorganic phosphate cotransporter), member 6b | slc17a6; vglut2a | D, V | La, A | Bae et al., 2009; Appelbaum 2009 | M, V | Aizawa et al., 2012 |
| solute carrier family17 (sodium- dependent inorganic phosphate cotransporter), member 7 | slc17a7; vglut1 | D (L>R) | A | Bae et al., 2009 | M | Aizawa et al., 2012 |
| spondin 1b | spon1b | D, V | La, A | Gamse et al., 2003; Akle et al., 2012 | M | AB atlas |
| synuclein, gamma b | sncgb | D (L>R) | La, A | Milanese et al., 2012 Chen et al., 2009 | M | Quina et al., 2009 |
| tachykinin 1 | tac1 | D (R>L) | A | Hong et al., 2013 | M | Quina et al., 2009; Aizawa et al., 2012 |
| tachykinin 3a (formerly tac2a) | tac3 | D (R>L), V? | La, A | Biran et al., 2012; Ogawa et al., 2012 | No homolog | AB atlas |
| transient receptor potential cation channel, subfamily C, member 1 | trpc1 | D (L>R) | La | von Niederhäusern et al., 2013 | M, L | AB atlas |
| transient receptor potential cation channel, subfamily C, member 5a | trpc5a | D, V? | La | von Niederhäusern et al., 2013 | M, L? | Fowler et al., 2007 |
| transient receptor potential cation channel, subfamily M, member 3 | trpm3 | D, V | La | Kastenhuber et al., 2013 | M | Oberwinkler et al., 2005 |
| unc-51-like kinase 2 | ulk2 | D (R>L), V | La | Taylor et al., 2011 | Neither | AB atlas |
| uncoupling protein 2 | ucp2 | D, V | A | Tseng et al., 2011 | Neither | AB atlas |
| vertebrate ancient long opsin b | valopb | D, V? | La | Kojima et al., 2008 | Neither | AB atlas |
| wingless-type MMTV integration site family, member 4a | wnt4a | D | La | Hendricks et al., 2008 | Neither | AB atlas |