Table 1.
Main summary of the recent 3 meta-analyses on lichen planus and hepatitis C virus
| Ref. | Country | Period covered by search | Type of studies included | Studies included in the meta-analysis | Cases/controls | Main results |
Quality assessment of the included studies |
1Quality assessment of the systematic review process | |
| Tool used | |||||||||
| Shengyuan et al[15] | China | NA | Case control or control-existing studies | 70 | 24987/65022 | The prevalence of HCV exposure among patients with LP was higher than in control participants (OR = 5.4; 95%CI: 3.5-8.3) | Yes | According to Robinson et al[17] | High |
| Clinical or histological LP diagnosis | 58 on HCV prevalence in LP | 35570/139120 | The risk of LP among patients with HCV was higher than compared controls (OR = 2.5; 95%CI: 2.0-3.1) | ||||||
| HCV status diagnosed by serology or PCR | 12 on LP prevalence in HCV+ | ||||||||
| Lodi et al[13] | Italy | Jan 1966-Nov 2007 | Controlled studies | 39 | 22544/2860 | LP patients have significantly higher risk than controls of being HCV seropositive (OR = 4.85; 95%CI: 3.58-6.56) | Yes | Characteristics of the study group, appropriateness of the control group, prospective design | High |
| Clinical and histological LP diagnosis | 33 on HCV prevalence in LP; 6 on LP prevalence in HCV+ | 3955/1242 | HCV patients have an increased risk of having LP (OR = 4.47; 95%CI: 1.84-10.86) | ||||||
| HCV status diagnosed by serology | |||||||||
| Petti et al[14] | Italy | NA | Cross-sectional or case- control studies | 44 | NA | The overall risk for OLP among anti-HCV positive subjects was significantly higher than controls (OR = 2.8; 95%CI: 2.4-3.2) | No | NA | Uncertain |
| Clinical or histological LP diagnosis. Any HCV testing | The fraction of global OLP cases associated with HCV (population attributable fraction) was 2.1% (95%CI: 1.9%-2.2%) | ||||||||