Table 2.
Accuracy of noninvasive diagnosis methods for nonalcoholic steatohepatitis
| Cutoff value | AUROC | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Ref. | |
| Biomarkers | |||||||
| Morbidly obese and AST, ALT | 2 times of ULN | - | - | - | 21 | 91 | [22] |
| big-γ GT | 2.6 U/L | 0.85 | 74 | 81 | 83.7 | 71.2 | [27] |
| CK-18 M30 antigen | 121.6 IU/L | 0.787 | 60 | 97.4 | 96.4 | 67.3 | [48] |
| CK-18 M65 antigen | 243.82 IU/L | 0.809 | 68.9 | 81.6 | 81.6 | 68.9 | [48] |
| PIIINP | 6.6 ng/mL | - | 80 | 68 | 60 | 85 | [51] |
| Predictive Models | |||||||
| APRI | 0.98 | 0.85 | 75 | 86 | 34 | 93 | [55] |
| FIB-4 | 1.30 | 0.86 | 85 | 65 | 36 | 95 | [59] |
| Image assessment | |||||||
| Transient elastography (TE; FibroScan ) | 6.7 kPa | 0.87 | 77.5 | 86.7 | 94.8 | 54.9 | [66] |
| ARFI | 1.2 m/s | 0.84 | 76.9 | 86.7 | 95.7 | 54.1 | [66] |
| Combine TE and ARFI | TE > 6.7 kPa ARFI > 1.2 m/s | - | 60.5 | 93.3 | 96.8 | 41.4 | [66] |
| MRE | 2.74 kPa | 0.93 | 94 | 73 | 85 | 89 | [71] |
ULN: Upper limit of normal; PIIINP: Terminal peptide of procollagen III; APRI: AST-to-platelet ratio index; AFRI: Acoustic radiation force impulse; MRE: Magnetic resonance elastography; AUROC: Area under receiver operating characteristic curve; PPV: Positive predictive value; NPV: Negative predictive value.