Figure 1.

Mature microRNAs silenced by aberrant DNA methylation and their affected target genes and pathways that are important in the development and progression of hepatocellular carcinoma. PI3K: Phosphatidylinositol-3-kinase; MAPK: Mitogen-activated protein kinase; EGF: Epidermal growth factor; PDGF: Platelet-derived growth factor; HGF: Hepatocyte growth factor; mTOR: Mammalian target of rapamycin; VEGF: Vascular endothelial growth factor; MMP: Matrix metalloproteinase; APC: Activated protein C; CTNNB1: Beta-catenin.