Table 2.
MicroRNA genes targeted by DNA hypermethylation in hepatocellular carcinoma
| MicroRNA | Validated gene targets in HCC | Biological functions | Ref. |
| miR-1 | FoxP1, MET, HDAC4 | Regulates cell growth, replication and clonogenic survival | [164-166] |
| miR-10a | HOXB3, HOXA3, HOXA1, HOXD10, USF2, HOXD4 | Regulates embryonic development and cell differentiation | [167] |
| miR-124 | CDK6, VIM, SMYD3, E2F6, IQGAP1 | Regulates cell cycle progression (G1-S checkpoint), apoptosis, and metastasis | [166,168] |
| miR-1247 | ADAM15, CIT, MMP24 | Regulates cell proliferation and migration | [166] |
| miR-125b | PIGF, MMP2, MMP9, SIRT7, LIN28B | Regulates cell proliferation, anchorage-independent growth, cell migration, invasion, and angiogenesis | [169] |
| miR-129-2 | SOX4, VCP, IκBα | Regulates apoptosis | [166,170] |
| miR-132 | AKT1, CTNNB1, CCND1 | Regulates cell proliferation | [171] |
| miR-203 | ABCE1, CDK6 | Regulates cell growth and cell cycle progression | [168] |
| miR-320 | NRP1, CTNNB1 | Regulates cell migration, proliferation, and metasatasis | [167] |
| miR-335 | ROCK1, MAPK1, LRG1, MYCN | Regulates migration and cell proliferation | [172] |
| miR-596 | LGALS3BP, FOXP1, IGF2BP2 | Regulates cell growth and induces apoptosis | [166] |
| miR-663 | JUNB, JUND, | Regulates cell proliferation | [165] |
| miR-9 | MTHFD2, HOXD1, MMP14 | Regulates cell proliferation, invasion, metastasis, and angiogenesis | [166] |
HCC: Hepatocellular carcinoma.