Table 3.
No. | Panther | Genes | Gene | Contrib |
GO molecular function1 | ||||
1 | Binding (GO:0005488) | 2799 | 40.60% | 33.80% |
2 | Catalytic activity (GO:0003824) | 2126 | 30.80% | 25.70% |
3 | Transcription regulator activity (GO:0030528) | 920 | 13.30% | 11.10% |
4 | Receptor activity (GO:0004872) | 696 | 10.10% | 8.40% |
5 | Structural molecule activity (GO:0005198) | 558 | 8.10% | 6.70% |
6 | Enzyme regulator activity (GO:0030234) | 494 | 7.20% | 6.00% |
7 | Transporter activity (GO:0005215) | 418 | 6.10% | 5.00% |
8 | Ion channel activity (GO:0005216) | 152 | 2.20% | 1.80% |
9 | Translation regulator activity (GO:0045182) | 57 | 0.80% | 0.70% |
10 | Motor activity (GO:0003774) | 53 | 0.80% | 0.60% |
GO Biological process2 | ||||
1 | Metabolic process (GO:0008152) | 3277 | 47.50% | 20.80% |
2 | Cellular process (GO:0009987) | 2564 | 37.20% | 16.30% |
3 | Cell communication (GO:0007154) | 1793 | 26.00% | 11.40% |
4 | Developmental process (GO:0032502) | 1315 | 19.10% | 8.40% |
5 | Transport (GO:0006810) | 1190 | 17.30% | 7.60% |
6 | Immune system process (GO:0002376) | 956 | 13.90% | 6.10% |
7 | System process (GO:0003008) | 927 | 13.40% | 5.90% |
8 | Cell cycle (GO:0007049) | 797 | 11.60% | 5.10% |
9 | Cellular component organization (GO:0016043) | 630 | 9.10% | 4.00% |
10 | Response to stimulus (GO:0050896) | 613 | 8.90% | 3.90% |
GO cellular component3 | ||||
1 | Intracellular (GO:0005622) | 486 | 7.10% | 50.40% |
2 | Extracellular region (GO:0005576) | 233 | 3.40% | 24.10% |
3 | Plasma membrane (GO:0005886) | 86 | 1.20% | 8.90% |
4 | Ribonucleoprotein complex (GO:0030529) | 84 | 1.20% | 8.70% |
5 | Protein complex (GO:0043234) | 76 | 1.10% | 7.90% |
GO protein class4 | ||||
1 | Nucleic acid binding (PC00171) | 1144 | 16.60% | 12.60% |
2 | Transcription factor (PC00218) | 920 | 13.30% | 10.20% |
3 | Hydrolase (PC00121) | 691 | 10.00% | 7.60% |
4 | Receptor (PC00197) | 690 | 10.00% | 7.60% |
5 | Transferase (PC00220) | 662 | 9.60% | 7.30% |
6 | Enzyme modulator (PC00095) | 634 | 9.20% | 7.00% |
7 | Signaling molecule (PC00207) | 481 | 7.00% | 5.30% |
8 | Transporter (PC00227) | 457 | 6.60% | 5.00% |
9 | Cytoskeletal protein (PC00085) | 402 | 5.80% | 4.40% |
10 | Kinase (PC00137) | 316 | 4.60% | 3.50% |
Pathway5 | ||||
1 | Gonadotropin releasing hormone receptor pathway (P06664) | 159 | 2.30% | 4.80% |
2 | Wnt signaling pathway (P00057) | 156 | 2.30% | 4.70% |
3 | Inflammation mediated by chemokine and cytokine signaling pathway (P00031) | 134 | 1.90% | 4.00% |
4 | Integrin signalling pathway (P00034) | 116 | 1.70% | 3.50% |
5 | Angiogenesis (P00005) | 98 | 1.40% | 3.00% |
6 | EGF receptor signaling pathway (P00018) | 84 | 1.20% | 2.50% |
7 | Cadherin signaling pathway (P00012) | 80 | 1.20% | 2.40% |
8 | Huntington disease (P00029) | 77 | 1.10% | 2.30% |
9 | TGF-beta signaling pathway (P00052) | 73 | 1.10% | 2.20% |
10 | PDGF signaling pathway (P00047) | 74 | 1.10% | 2.20% |
KEGG | ||||
hsa01100 metabolic pathways (434) | ||||
hsa05200 pathways in cancer (189) | ||||
hsa04151 PI3K-Akt signaling pathway (162) | ||||
hsa04010 MAPK signaling pathway (137) | ||||
hsa05205 proteoglycans in cancer (134) | ||||
hsa05166 HTLV-I infection (123) | ||||
hsa04510 Focal adhesion (116) | ||||
hsa04810 regulation of actin cytoskeleton (115) | ||||
hsa05202 transcriptional misregulation in cancer (100) | ||||
hsa04144 endocytosis (100) |
Total genes n = 6893, total function hits n = 8282;
Total genes n = 6893, total process hits n = 15740;
Total genes n = 6893, total component hits n = 965;
Total genes n = 6893, total protein classess n = 9050;
Total genes n = 6893, total pathway hits n = 3313. Contrib: Contribution; PI3K: Phosphatidylinositol-3-kinase; MAPK: Mitogen-activated protein kinase; HTLV: Human T-lymphotropic virus 1; EGF: Epidermal growth factor; PDGF: Platelet-derived growth factor; TGF-β: Transforming growth factor beta.