Figure 1.

OPHN1–Homer interaction is critical for LTP. A, B, LTP was induced in CA1 neurons infected with indicated lentivirus (A) or incubated with indicated peptides (B) using a pairing protocol. Top, Representative traces of AMPAR-mediated EPSCs before (1) and after (2) LTP induction. Calibration: 20 pA, 20 ms. Bottom, Normalized AMPAR-mediated EPSCs before and after LTP induction for induced pathway (closed symbols) and control pathway (open symbols). Error bars represent SEM; n = 7 (for A and B), *p < 0.05 measured between 40 and 45 min, Mann–Whitney test.