Figure 5.

Two intracellular slow-wave patterns recorded from the mouse thalamus. A, Simultaneously recorded intracellular activities of thalamic and cortical S1 neurons and contralateral EEG during the slow oscillation in anesthetized mice. Left, The thalamic neuron reveals a characteristic LTS in response to a hyperpolarizing (100 ms, 0.5 nA) current pulse. During cortical depolarizing active states, the TC neuron displayed unitary or repetitive IPSPs. Thalamic IPSPs follow the onset of cortical active states. B, A segment of EEG and intracellular activities recorded from another pair of thalamic (AD) and cortical neurons. A morphologically identified thalamic neuron (left) did not generate LTS in response to a hyperpolarizing current pulse (inset) of different amplitude (data not shown). The thalamic neuron generated active states composed of multiple depolarizing events that followed cortical active states. There is a time delay between the onset of intracellular cortical and thalamic active states (right).