Enhanced IL-1β and CCL2 mRNA expression in adult WT mice after SCI. A, B, Adult female (3–4 months) and aged female (18–22 months) BALB/c mice, and (C, D) adult male WT (2–4 months) and adult male (3–4 months) IL-4Rα-deficient (IL-4RαKO) BALB/c mice were subjected to a T9 laminectomy (Lam) or SCI. Two 1 mm sections of spinal cord were collected adjacent to the epicenter. mRNA expression of (A, C) IL-1β and (B, D) CCL2 (n = 4–5). Error bars represent the mean ± SEM. Means with *p < 0.05 are significantly different from Age-matched and genotype-matched-Lam controls. Means with #p < 0.0001 are significantly different and means with +p = 0.09 tend to be different from Time point-matched Adult-SCI or WT-SCI groups.