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Phylogenetic tree of DnaE2. The tree is constructed by using MEGA 5.0 under JTT+Γ4 model (with 100 bootstraps). Ten randomly selected DnaE1 sequences from Actinobacteria are used as outgroup (in gray color). Terrabacteria are colored in blue. Horizontally transferred DnaE2 sequences are colored in red. The main topology of DnaE2 tree is validated by a more comprehensive data set of outgroup using both neighbor-joining (NJ) and maximum likelihood (ML) methods (Supplementary Figure S2).
