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. 2014 Jun 12;26(3):363–373. doi: 10.5021/ad.2014.26.3.363

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Copyright © 2014 The Korean Dermatological Association and The Korean Society for Investigative Dermatology

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 3 — Expression of matrix metalloproteinase (MMP)-2 and -9 protein and mRNA in SK-MEL-2 and SK-MEL-24 cell lines following incubation with imiquimod. Expression of MMP-2 decreased with increasing concentrations of imiquimod in SK-MEL-2 cells (A) and SK-MEL-24 cells (B). (C) MMP-9 expression in SK-MEL-2 cells was increased by imiquimod treatment in a dose-dependent manner. (D) However, expression of MMP-9 was dose-dependently decreased in SK-MEL-24 cells treated with imiquimod. Conditioned media of the HT1080 cell line was used as a positive control. Relative mRNA expression of MMP-2 in SK-MEL-2 (E) and SK-MLE-24 (F) cells and MMP-9 in SK-MEL-2 (G) and SK-MLE-24 (H) cells, following incubation with a range of concentrations of imiquimod (5, 10, and 30 µg/ml), compared to controls (0 µg/ml). ^*p<0.05 vs. control.