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. 2014 Jun 12;26(3):363–373. doi: 10.5021/ad.2014.26.3.363

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Copyright © 2014 The Korean Dermatological Association and The Korean Society for Investigative Dermatology

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 5 — Expression of tissue inhibitors of metalloproteinase (TIMP)-1 and -2 protein and mRNA in SK-MEL-2 and SK-MEL-24 cell lines following incubation with imiquimod. Expression of TIMP-1 protein was dose-dependently increased by imiquimod in SK-MEL-2 (A) and SK-MEL-24 cells (B). Expression of TIMP-2 protein was also dose-dependently elevated by imiquimod in SK-MEL-2 (C) and SK-MEL-24 cells (D). Relative mRNA expression of TIMP-1 in SK-MEL-2 (E) and SK-MLE-24 (F) cells and TIMP-2 in SK-MEL-2 (G) and SK-MLE-24 (H) cells, following treatment with a range of concentrations of imiquimod (5, 10, and 30 µg/ml), compared to controls (0 µg/ml). ^*p<0.05 vs. control.