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. 2014 Jun 25;34(3):e00112. doi: 10.1042/BSR20140020

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© 2014 The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Licence (CC-BY)(http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (CC-BY) (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.

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(A) MET expression was significantly decreased after transfection with miR-34a mimics, but MET expression could be restored by overexpressing MET. (B,C) The tumourigenic qualities of MKN45 cells were inhibited by the forced expression of miR-34a and were partially restored by the overexpression of MET or PDGFR. MKN45 gastric cancer cell migration, invasion and proliferation were completely restored only after overexpressing both PDGFR and MET.