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. 2014 Jun 25;5:105. doi: 10.3389/fneur.2014.00105

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Copyright © 2014 Engström, Hallböök, Szakacs, Karlsson and Landtblom.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Brain activation in Kleine–Levin syndrome (KLS) during working memory performance. The orange areas show typical working memory activation in the executive network in healthy individuals. Pink areas show regions with hyperactivation in KLS patients. The main finding of thalamic hyperactivation is marked with a pink arrow. The white arrow marks areas within the orange activation cluster in the anterior cingulate cortex and adjacent medial prefrontal cortex where KLS patients had less activation compared to the healthy control group. Data include 18 KLS patients and 18 matched controls (23).