Table 2.
Apelin expression in normal liver and different stages of chronic HCV liver disease
| Fibrosis stage | n | Apelin expression in | |||||
|---|---|---|---|---|---|---|---|
|
| |||||||
| Non-parenchymatous cells | P valuea | Hepatocytes | P valuea | ||||
|
|
|
||||||
| Mean ± SD | Median | Mean ± SD | Median | ||||
| Normal liver | 5 | 0 ± 0.0 | 0 | < 0.001 | 0 ± 0.0 | 0 | 0.796 |
| F1 | 8 | 0.125 ± 0.35 | 0 | 0.375 ± 0.51 | 0 | ||
| F2 | 15 | 0.33 ± 0.48 | 0 | 0.2 ± 0.41 | 0 | ||
| F3 | 20 | 0.6 ± 0.598 | 1 | 0.2 ± 0.41 | 0 | ||
| F4 | 18 | 2.5 ± 1.2 | 3 | 0.11 ± 0.32 | 0 | ||
Non parenchymatous: sinusoidal endothelial cells/hepatic stellate cells, myofibroblasts, endothelial cells.
a
P-value presents the differences between all groups.
Apelin in non-parenchymatous cells in: Normal versus F1, p = 0.429. Normal versus F2, p = 0.146. Normal versus F3, P = 0.032. F1 versus F2, P = 0.289. F2 versus F3, P = 0.181. F3 versus F4, P < 0.001. Significant P-values are in bold.