Table 1.
Summary of Nogo-C interacting proteins identified
| Accession | Annotationa | mW (Da) | Peptidesb | PLGS | pI (pH) | molecular functionc |
|---|---|---|---|---|---|---|
|
| ||||||
| Score | ||||||
| structural molecule | ||||||
| IPI00478908.3 | TUBA1C | 28545 | 4 | 24.9027 | 5.0944 | SCOC; GTP-A |
| IPI00007752.1 | TUBB2C | 49799 | 7 | 25.3933 | 4.602 | SCOC; GTP-A |
| IPI00387144.5 | TUBA1B | 57723 | 4 | 10.9827 | 4.7631 | SMA; GTP-A |
| IPI00791613.1 | TUBA8 | 51951 | 2 | 7.4946 | 4.9852 | SCOC; GTP-A |
| IPI00295857.7 | COPA | 138257 | 13 | 19.4444 | 7.4464 | SMA |
| IPI00646493.1 | COPA | 139235 | 5 | 7.1371 | 7.3354 | SMA |
| IPI00386712.1 | MYL4 | 21550 | 2 | 15.736 | 4.7834 | SCOM; AF-B |
| binding | ||||||
| IPI00011253.3 | RPS3 | 26671 | 6 | 27.1605 | 10.0402 | SCOR |
| IPI00878297.1 | RPS2 | 29984 | 4 | 24.9084 | 8.9835 | SCOR; FGF-B |
| IPI00877699.1 | TRIOBP | 28939 | 7 | 21.4844 | 5.5144 | MGRA-B |
| IPI00014149.3 | TTC35 | 34811 | 3 | 14.1414 | 6.1335 | binding |
| IPI00029266.1 | SNRPE | 10796 | 2 | 25 | 9.7804 | DR-B; RNA-S |
| IPI00644224.2 | HNRNPU | 86806 | 14 | 27.551 | 6.0108 | DRP-B |
| IPI00908896.1 | HNRNPH | 16838 | 2 | 30.1887 | 4.821 | RP-B |
| IPI00644079.2 | HNRNPU | 90527 | 14 | 1222.6204 | 5.6479 | RP-B |
| IPI00643152.2 | HSP70 | 77513 | 8 | 17.305 | 8.1035 | PA-B |
| IPI00910482.1 | HSP70 | 61492 | 10 | 445.444 | 5.2773 | PA-B |
| IPI00878876.1 | SNRPD3 | 13282 | 2 | 15.8333 | 9.2411 | RP-B |
| IPI00167147.1 | HNRNPU | 90235 | 11 | 25.3731 | 6.4883 | RP-B |
| IPI00219037.5 | H2AFX | 15135 | 2 | 11.1888 | 11.1559 | DP-B |
| IPI00642249.1 | AMOT | 68350 | 4 | 8.7102 | 8.016 | P-B |
| IPI00028888.1 | HNRNPD | 38410 | 3 | 9.5775 | 7.8979 | DP-B; TF |
| IPI00479191.2 | HNRNPH | 51197 | 5 | 32.4153 | 6.3431 | DRP-B |
| IPI00013877.2 | HNRNPH | 36903 | 3 | 11.2717 | 6.3999 | RP-B |
| IPI00479217.1 | HNRNPU | 88924 | 14 | 25.6824 | 5.4659 | DRPA-B |
| IPI00217030.10 | RPS4X | 29579 | 5 | 28.1369 | 10.5861 | D-B |
| IPI00916188.1 | NCL | 32427 | 4 | 21.8855 | 5.0956 | RP-B |
| IPI00604620.3 | NCL | 76568 | 4 | 139.2712 | 4.4004 | RP-B |
| IPI00402185.4 | SYNCRIP | 46299 | 3 | 9.5122 | 9.1055 | PS; RP-B |
| IPI00641719.1 | SURF4 | 21113 | 5 | 19.3548 | 6.0936 | P-B |
| IPI00399142.5 | SURF4 | 21115 | 2 | 21.8085 | 8.7072 | P-B |
| IPI00023673.1 | LGALS3BP | 65289 | 3 | 11.453 | 4.9438 | P-B |
| IPI00887555.1 | LGALS3BP | 61605 | 4 | 86.0234 | 5.1229 | P-B |
| IPI00889009.1 | RPL23A | 22681 | 3 | 11.1111 | 10.5355 | SCOR; DRP-B |
| IPI00455428.3 | RPS2 | 29745 | 4 | 13.8182 | 10.3555 | SCOR; FGF-B |
| IPI00888294.1 | RPS2 | 25528 | 4 | 18.4549 | 10.2367 | SCOR; FGF-B |
| IPI00187140.1 | RPS26 | 12993 | 2 | 18.2609 | 10.9547 | SCOR; RP-B |
| IPI00886830.1 | RPS16 | 18223 | 2 | 10.9756 | 9.4964 | SCOR; RP-B |
| IPI00397609.2 | RPS18 | 17627 | 5 | 28.9474 | 10.7721 | SCOR; R-B |
| IPI00909890.1 | FUS | 44785 | 8 | 24.9417 | 9.1479 | DRPI-B |
| IPI00260715.5 | FUS | 53344 | 7 | 675.9695 | 9.559 | DRPI-B |
| IPI00045801.3 | FIZ1 | 51960 | 2 | 5.0403 | 8.0577 | DPI-B |
| IPI00397701.3 | RPS16 | 16401 | 4 | 26.7123 | 10.3768 | RP-B |
| IPI00456429.3 | UBA52 | 14718 | 3 | 27.3438 | 10.2647 | P-B |
| IPI00789951.2 | CALML4 | 21459 | 3 | 15.8974 | 6.7083 | Ca2+-B |
| IPI00478437.3 | CALML4 | 21869 | 2 | 14.7959 | 7.4013 | Ca2+-B |
| IPI00014456.4 | STRN | 86078 | 4 | 6.5385 | 4.9459 | Ca2+-B; CA |
| IPI00219806.7 | S100A7 | 11463 | 2 | 21.7822 | 6.3404 | ZI/Ca2+-B |
| IPI00845339.1 | HSP70 | 69995 | 21 | 34.4774 | 5.3154 | DPA-B; UPL-B |
| IPI00005667.4 | N4BP1 | 100345 | 6 | 11.8304 | 5.0488 | MI-B |
| signal transducer | ||||||
| IPI00873380.1 | Nogo C | 22238 | 25 | 43.2161 | 9.5266 | ST; P-B |
| IPI00021766.5 | RTN4 | 129851 | 22 | 7.047 | 4.2241 | ST; P-B |
| IPI00298289.1 | RTN4 | 40292 | 10 | 26.2735 | 4.4905 | ST; P-B |
| IPI00219207.1 | RTN4 | 22381 | 27 | 34.6734 | 9.6482 | ST; P-B |
| IPI00477663.1 | RTN4 | 106294 | 21 | 6.9792 | 4.2167 | ST; P-B |
| IPI00894099.1 | RTN4 | 22791 | 9 | 28.5714 | 9.0452 | ST; P-B |
| IPI00478442.3 | RTN4 | 42247 | 7 | 18.3673 | 4.4485 | ST; P-B |
| IPI00894213.1 | RTN4 | 108382 | 3 | 5.2738 | 4.3154 | ST; P-B |
| IPI00220880.1 | RGS20 | 31465 | 4 | 24.9084 | 5.04 | ST; P-B |
| IPI00303797.3 | B-RAF | 84383 | 2 | 179.4723 | 7.2643 | MAPKKK |
| IPI00020898.1 | RPS6KA3 | 83683 | 5 | 12.8378 | 6.4204 | MAPKKK |
| transcription regulator activity | ||||||
| IPI00641665.1 | ILF2 | 12374 | 4 | 63.4783 | 4.8984 | TF |
| IPI00011274.3 | HNRPDL | 46409 | 5 | 14.5238 | 9.8221 | TF; DRP-B |
| IPI00798127.1 | UBC | 76981 | 3 | 4.9635 | 7.7573 | T; COR |
| IPI00798155.4 | UBC | 12229 | 4 | 29.2453 | 10.5756 | T; COR |
| IPI00556173.1 | ILF3 | 76454 | 5 | 9.3484 | 7.853 | TR; I-B |
| IPI00298788.4 | ILF3 | 95279 | 5 | 9.9553 | 8.9555 | TF |
| transporter | ||||||
| IPI00797148.1 | HNRNPA1 | 29368 | 7 | 33.3333 | 9.4607 | RNA TT |
| IPI00879501.2 | HNRNPA1 | 34204 | 5 | 16.875 | 9.2814 | RNA TT |
| IPI00644968.1 | HNRNPA1 | 34202 | 6 | 23.75 | 9.4684 | RNA TT |
| IPI00176692.7 | HNRNPA1 | 32142 | 5 | 495.4168 | 9.1154 | RNA TT |
| IPI00478539.2 | HNRNPA1 | 32360 | 5 | 21.5947 | 9.1631 | RNA TT |
| unknown function | ||||||
| IPI00902571.1 | TNRC18 | 169808 | 5 | 7.8076 | 7.1545 | unknown |
| IPI00186448.7 | TNRC18 | 64571 | 3 | 10.2564 | 10.2389 | unknown |
The gene name encoding for each protein identified;
Number of unique peptides found for each protein identified;
SCOC, structural constituent of cytoskeleton;
GTP-A, GTP activation; SMA, structural molecule activity; SCOM, structural constituent of muscle; SCOR, structural constituent of ribosome; RNA-B, RNA binding; FGF-B, FGF binding; MGRA-B, myosin/GTP-Rho/actin binding; DRP-B, DNA/RNA/protein binding; D-B, DNA binding; DR-B, DNA/RNA binding; RNA-S, RNA splicing; RP-B, RNA/protein binding; PA-B, protein/ATP binding; DP-B, DNA/protein binding; P-B, protein binding; TF, transcription factor; DRPA-B, protein/RNA/DNA/ATP binding; PS, protein stabilization; DRPI-B, DNA/RNA/protein/ion binding; DPI-B, protein kinase/DNA/ion binding; Ca2+-B, Ca2+ binding; CA, catalytic activity; ZI/Ca2+-B, zinc ion/Ca2+ binding; MI-B, metal ion binding; ST, signal transducer; MAPKKK, MAP kinase kinase kinase activity; COR, constituents of ribosome; TR, transcription repressor; I-B, ion binding; DPA-B, DNA/Protein/ATP binding; UPL-B, ubiquitin protein ligase binding; RNA TT, RNA transmembrane transporter; R-B, RNA binding; AF-B, actin filament binding.