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. 2014 Apr 15;7(5):2006–2018.

Figure 2.

Figure 2

Role of an A2BAR antagonist on TJ mRNA levels under hypoxia and I/R. Caco-2 cells were pretreated with or without PSB1115, and the monolayers were then subjected to hypoxia for 6 h. The mRNA levels of the TJs were determined using RT-PCR. The data are the mean ± SD (n = 6). A-C. Hypoxia down-regulated claudin-1, occludin and ZO-1 mRNA expression, and PSB1115 attenuated the down-regulation of these TJs as induced by hypoxia. D-F. I/R down-regulated claudin-1, occludin and ZO-1 mRNA expression, and PSB1115 attenuated the down-regulation of TJ mRNA expression induced by I/R (*P < 0.05, **P < 0.01 compared to the Nx group and Sham group; ***P < 0.05, compared to the Hx. #P < 0.01, compared to the I/R group).