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. 2014 Jun 7;9:80. doi: 10.1186/1750-1172-9-80

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Copyright © 2014 Kambouris et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Diagrams of the 3D model of ZNF407 tandem finger domains (rainbow colored) and a double-stranded DNA sequence (phosphate backbone in orange and bases as green-to-blue sticks). a: Wild type finger 19-finger 20 linker with p.P1713 and p.E1711 (positions i + 4 and i + 2, respectively). b: Wild type fingers 18 and 19 with linker peptide showing p.S1685 H-bonded to p.E1683. One zinc ion is coordinated by each finger (grey spheres). c: p.S1685W mutant showing the loss of the H-bond to p.E1683.