Table 3.
Multivariable (Cox Proportional Hazards) Predictor Model of Mortality in Patients on βAR Blockade (n = 1,267)
| 95% CI |
||||
|---|---|---|---|---|
| Predictor | HR | Lower | Upper | P Value |
| Sex | ||||
| Female | 1* | |||
| Male | 1.27 | 0.81 | 2.00 | 0.308 |
| Age (yr) | 1.05 | 1.03 | 1.07 | <0.001 |
| Preoperative LVEF (%) | 0.97 | 0.96 | 0.99 | <0.001 |
| Diabetes mellitus | ||||
| No | 1* | |||
| Yes | 1.49 | 1.04 | 2.13 | 0.030 |
| Pulmonary disease | ||||
| No | 1* | |||
| Yes | 1.49 | 0.96 | 2.18 | 0.075 |
| Creatinine concentration (mg/dl) | 1.68 | 1.10 | 2.56 | 0.015 |
| Hematocrit (%) | 0.95 | 0.90 | 0.99 | 0.014 |
| NYHA | 1.27 | 1.04 | 1.56 | 0.019 |
| Number of grafts | 0.71 | 0.55 | 0.92 | 0.008 |
| GNAS diplotype | ||||
| *3/*3 | 1* | |||
| *3/*2 | 1.27 | 0.61 | 2.62 | 0.521 |
| *3/*1 | 1.51 | 0.74 | 3.07 | 0.252 |
| *2/*2 | 1.33 | 0.58 | 3.04 | 0.502 |
| *2/*1 | 2.27 | 1.14 | 4.53 | 0.020 |
| *1/*1 | 3.02 | 1.50 | 6.11 | 0.002 |
Clinical and demographic variables were selected based on association (P < 0.1) in univariate analysis or when part of the EuroSCORE II.
*
Reference.
βAR = β-adrenoreceptor; HR = hazard ratio; LVEF = left ventricular ejection fraction; NYHA = New York Heart Association.