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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Cell Stem Cell. 2014 May 1;14(5):673–688. doi: 10.1016/j.stem.2014.03.002

Figure 1. Transcriptome alterations with HSC aging.

Figure 1

(A) Gene ontology enrichment analysis for 2140 differentially expressed genes with HSC aging; X-axis shows the P value.

(B) The distribution of expression changes for ribosomal protein genes during HSC aging, where the x-axis value is FPKM difference between Old and Young HSC.

(C) Average FPKM value of genes encoding epigenetic modifiers in young and old HSCs.

(D) HPLC-mass-spectrometry measurements of 5-hydroxy methylcytosine (5hmc) levels as a proportion of the total cytosine in purified HSCs from 4mo, 12mo and 24mo old mice (n=7). ** P< 0.01. Error bars represent Mean ± SEM.

(E) Differential expression of repetitive elements during HSC. Each row represents a repeat location in the genome. Blue denotes low and yellow high expression (log2 reads number).

See also Figures S1, and S2

HHS Vulnerability Disclosure