Table 1.
Patients' clinical characteristics.
| All patients (N = 135) | Not treated with statins (N = 47) | Treated with statins (N = 88) | P | |
|---|---|---|---|---|
| Gender: male/female [number (%)] | 78 (57.8)/57 (42.2) | 27 (57.4)/20 (42.6) | 51 (58.0)/37 (42.0) | 1.000a |
| Age (years) [median (25%–75%)] | 64 (59–70) | 64 (57–70) | 65 (60–70) | 0.310b |
| BMI (kg/m2) [median (25%–75%)] | 29 (28–34) | 29 (28–32) | 30 (28–34) | 0.545b |
| BMI > 30 [number (%)] | 55 (40.7) | 16 (34.0) | 39 (44.3) | 0.274a |
| BMI > 35 [number (%)] | 23 (17.0) | 6 (12.8) | 17 (19.3) | 0.354a |
| Duration of diabetes (years) [median (25%–75%)] | 11 (6–16) | 11 (5–16) | 10 (7–15) | 0.967b |
| Duration of metformin treatment (years) [median (25%–75%)] | 5 (4–8) | 5 (3–8) | 6 (4–8) | 0.487b |
| Metformin dose (mg) [median (25%–75%)] | 2550 (2000–2550) | 2550 (1700–2550) | 2550 (2000–2550) | 0.202b |
| HbA1c (%) [median (25%–75%)]d | 6.9 (6.4–7.6) | 6.7 (6.2–7.7) | 6.9 (6.5–7.6) | 0.424b |
| Glucose (mmol/L) [median (25%–75%)]e | 7.5 (6.7–8.8) | 7.6 (6.7–8.8) | 7.5 (6.7–8.8) | 0.854b |
| Patients with hypoglycemia [number (%)] | 28 (20.7) | 7 (14.9) | 21 (23.9) | 0.269a |
| Serum creatinine (μmol/L) [median (25%–75%)] | 75 (64–87) | 83 (64–91) | 73 (63.3–83) | 0.115b |
| eGF (mL/min) [median (25%–75%)] | 82 (68–90) | 78 (66–90) | 84 (68.3–90) | 0.473b |
| Urea (mmol/L) [median (25%–75%)] | 5.4 (4.4–6.6) | 5.3 (4.4–6.9) | 5.4 (4.3–6.4) | 0.872b |
| Albuminuria (mg/L) [median (25%–75%)] | 9 (3.7–35.7) | 7.1 (3.7–41.4) | 9.5 (3.7–35.6) | 0.642b |
| AST (μkat/L) [median (25%–75%)]c | 0.41 (0.35–0.50) | 0.39 (0.35–0.51) | 0.41 (0.35–0.50) | 0.785b |
| ALT (μkat/L) [median (25%–75%)]c | 0.45 (0.36–0.62) | 0.435 (0.36–0.54) | 0.48 (0.35–0.68) | 0.246b |
| GGT (μkat/L) [median (25%–75%)] | 0.42 (0.31–0.77) | 0.42 (0.32–0.90) | 0.42 (0.31–0.76) | 0.621b |
| Total cholesterol (mmol/L) [median (25%–75%)] | 4.3 (3.8–5.2) | 4.8 (4–5.6) | 4.1 (3.8–4.9) | 0.016b |
| LDL cholesterol (mmol/L) [median (25%–75%)] | 2.4 (1.9–3.3) | 3 (2.1–3.6) | 2.3 (1.9–2.9) | 0.001b |
| HDL cholesterol (mmol/L) [median (25%–75%)]c | 1.2 (1.0–1.4) | 1.3 (1–1.5) | 1.2 (1–1.4) | 0.342b |
| TAG (mmol/L) [median (25%–75%)] | 1.6 (1.3–2.4) | 1.5 (1.1–2) | 1.8 (1.3–2.7) | 0.029b |
aCalculated using Fisher exact test; bcalculated using Mann-Whitney U test; cdata missing for 1 patient; ddata missing for 3 patients; edata for 88 patients (28 not treated with statins and 60 treated with statins).